HIV Resistance Response Database Initiative (RDI) was formed in 2002 to use artificial intelligence (AI) to predict how patients will respond to HIV drugs using data from more 250,000 patients from around 50 countries around the world. The RDI used its models to power its HIV Treatment Response Prediction System (HIV-TRePS). Launched in 2010, this free online tool enabled healthcare professionals to upload their patient’s data and obtain highly accurate predictions of how they would respond to different combinations of the 30 or more drugs available. The tool enabled physicians to individualize their patients’ treatment, using these predictions based on more than a million patient-years of treatment experience. HIV-TRePS was possibly the first ever AI-based system for medical decision-making to be developed, successfully tested, and used in clinical practice. It has since been used by thousands of healthcare professionals to optimise the treatment of tens of thousands of patients. Since the RDI’s inception the treatment of HIV infection has progressed enormously, with more effective and better tolerated drugs available in ever more convenient combination formulations. In most countries HIV is now considered a chronic, manageable condition. Moreover, the success of the drugs in reducing the amount of virus is substantially reducing the onward transmission of the virus and cases of new infections are falling in many settings. This improvement in HIV treatment means the need for sophisticated AI to support HIV treatment decisions has significantly reduced. In response, the RDI ceased development of further models and, in March 2024, withdrew its HIV-TRePS system. == Background == Human immunodeficiency virus (HIV) is the virus that causes acquired immunodeficiency syndrome (AIDS), a condition in which the immune system begins to fail, leading to life-threatening opportunistic infections. There are approximately 30 HIV antiretroviral drugs that have been approved for the treatment of HIV infection, from six different classes, based on the point in the HIV life-cycle at which they act. They are used in combination; typically 3 or more drugs from 2 or more different classes, a form of therapy known as highly active antiretroviral therapy (HAART). The aim of therapy is to suppress the virus to very low, ideally undetectable, levels in the blood. This prevents the virus from depleting the immune cells that it preferentially attacks CD4 cells and prevents or delays illness and death. Despite the expanding availability of these drugs and the impact of their use, treatments continue to fail, often involving to the development of resistance. During drug therapy, low-level virus replication may still occur, particularly when a patient misses a dose. HIV makes errors in copying its genetic material and, if a mutation makes the virus resistant to one or more of the drugs in the patient's treatment, it may begin to replicate more successfully in the presence of that drug and undermine the effect of the treatment. If this happens, the treatment needs to be changed to re-establish control over the virus. == RDI's Approach == The RDI’s approach was to use artificial intelligence (including neural network and random forest models), trained with data from hundreds of thousands of patients, treated with different drugs in a variety of clinical settings all over the world, to predict how an individual patient will respond to any new combination of HIV drugs. The models were tested with independent data sets and consistently achieved accuracy of approximately 80%.
Israeli cybersecurity industry
The Israeli cybersecurity industry is a rapidly growing sector within Israel's technology and innovation ecosystem. Israel is internationally recognized as a powerhouse in the cybersecurity domain, with numerous cybersecurity startups, established companies, research institutions, and government initiatives. Tel Aviv itself is being ranked 7th in annual list of best global tech ecosystems, as reported by the Jerusalem Post. == History == The roots of Israel's cybersecurity industry can be traced back to the country's strong focus on national security and intelligence. The establishment of elite military units such as Unit 8200, the Israeli Intelligence Corps unit responsible for signals intelligence and code decryption, played a significant role in the development of cybersecurity expertise in the country. Many former members of Unit 8200 have gone on to establish successful cybersecurity companies or join existing organizations, bringing their unique skill sets and experience to the private sector. == Market overview == As of 2024, Israel housed more than 450 cybersecurity startups and companies. In 2023, the value of exits by Israeli tech companies reached $7.5 billion. Israel's cybersecurity industry is characterized by a high concentration of startups develop new technologies in areas such as network security, endpoint protection, data security, cloud security, and threat intelligence. In recent years, the sector has attracted significant investment from both local and international venture capital firms, as well as major technology companies such as Microsoft, Google, and IBM. Several Israeli cybersecurity companies have gained global recognition and success, with some being acquired by major corporations or conducting successful initial public offerings (IPOs). === Key Israeli cybersecurity companies === Some key Israeli cybersecurity companies include: Check Point Software Technologies CyberArk Cato Networks Radware Wiz === Financial activity === Israel’s cybersecurity sector has seen significant financial activity. As of 2023, mergers and acquisitions in the cybersecurity sector totaled $2.8 billion. In the first quarter of 2024, the sector secured $846 million in private funding. == Background == The military experience helped much. Israel's mandatory military service, combined with the expertise developed within elite units such as Unit 8200, has fostered a strong talent pool with practical experience in cybersecurity. Israel's thriving startup ecosystem, often referred to as the "Startup Nation," has fostered an environment of innovation and collaboration that has contributed to the growth of the cybersecurity industry. Israeli cybersecurity companies often collaborate with international partners, both in the private and public sectors, to share knowledge and develop joint solutions. === Government Initiatives and Support === The government also supported well through various initiatives, such as the Israel National Cyber Directorate (INCD), which works to strengthen cybersecurity defenses and promote the development of the sector. === Academic institutions === Israeli universities and research centers are involved in cybersecurity research and education, contributing to the development of new technologies and training the next generation of cybersecurity professionals. Academic Tech transfer offices in Israel also facilitate the commercialization of cybersecurity technologies. Some academic institutions with cybersecurity laboratories include: Tel Aviv University Technion Ben-Gurion University
Speech recognition
Speech recognition (automatic speech recognition (ASR), computer speech recognition, or speech-to-text (STT)) is a sub-field of computational linguistics concerned with methods and technologies that translate spoken language into text or other interpretable forms. Speech recognition applications include voice user interfaces, where the user speaks to a device, which "listens" and processes the audio. Common voice applications include interpreting commands for calling, call routing, home automation, and aircraft control. These applications are called direct voice input. Productivity applications include searching audio recordings, creating transcripts, and dictation. Speech recognition can be used to analyse speaker characteristics, such as identifying native language using pronunciation assessment. Voice recognition (speaker identification) refers to identifying the speaker, rather than speech contents. Recognizing the speaker can simplify the task of translating speech in systems trained on a specific person's voice. It can also be used to authenticate the speaker as part of a security process. == History == Applications for speech recognition developed over many decades, with progress accelerated due to advances in deep learning and the use of big data. These advances are reflected in an increase in academic papers, and greater system adoption. Key areas of growth include vocabulary size, more accurate recognition for unfamiliar speakers (speaker independence), and faster processing speed. === Pre-1970 === 1952 – Bell Labs researchers, Stephen Balashek, R. Biddulph, and K. H. Davis, built Audrey for single-speaker digit recognition. Their system located the formants in the power spectrum of each utterance. 1960 – Gunnar Fant developed and published the source–filter model of speech production. 1962 – IBM's 16-word "Shoebox" machine's speech recognition debuted at the 1962 World's Fair. 1966 – Linear predictive coding, a speech coding method, was proposed by Fumitada Itakura of Nagoya University and Shuzo Saito of Nippon Telegraph and Telephone. 1969 – Funding at Bell Labs came to a halt for several years after the company's head engineer, John R. Pierce, wrote an open letter criticizing speech recognition research. This defunding lasted until Pierce retired and James L. Flanagan took over. Raj Reddy was the first person to work on continuous speech recognition, as a graduate student at Stanford University in the late 1960s. Previous systems required users to pause after each word. Reddy's system issued spoken commands for playing chess. Around this time, Soviet researchers invented the dynamic time warping (DTW) algorithm and used it to create a recognizer capable of operating on a 200-word vocabulary. DTW processed speech by dividing it into short frames (e.g. 10 ms segments) and treating each frame as a unit. Speaker independence, however, remained unsolved. === 1970–1990 === 1971 – DARPA funded a five-year speech recognition research project, Speech Understanding Research, seeking a minimum vocabulary size of 1,000 words. The project considered speech understanding a key to achieving progress in speech recognition, which was later disproved. BBN, IBM, Carnegie Mellon (CMU), and Stanford Research Institute participated. 1972 – The IEEE Acoustics, Speech, and Signal Processing group held a conference in Newton, Massachusetts. 1976 – The first ICASSP was held in Philadelphia, which became a major venue for publishing on speech recognition. During the late 1960s, Leonard Baum developed the mathematics of Markov chains at the Institute for Defense Analysis. A decade later, at CMU, Raj Reddy's students James Baker and Janet M. Baker began using the hidden Markov model (HMM) for speech recognition. James Baker had learned about HMMs while at the Institute for Defense Analysis. HMMs enabled researchers to combine sources of knowledge, such as acoustics, language, and syntax, in a unified probabilistic model. By the mid-1980s, Fred Jelinek's team at IBM created a voice-activated typewriter called Tangora, which could handle a 20,000-word vocabulary. Jelinek's statistical approach placed less emphasis on emulating human brain processes in favor of statistical modelling. (Jelinek's group independently discovered the application of HMMs to speech.) This was controversial among linguists since HMMs are too simplistic to account for many features of human languages. However, the HMM proved to be a highly useful way for modelling speech and replaced dynamic time warping as the dominant speech recognition algorithm in the 1980s. 1982 – Dragon Systems, founded by James and Janet M. Baker, was one of IBM's few competitors. === Practical speech recognition === The 1980s also saw the introduction of the n-gram language model. 1987 – The back-off model enabled language models to use multiple-length n-grams, and CSELT used HMM to recognize languages (in software and hardware, e.g. RIPAC). At the end of the DARPA program in 1976, the best computer available to researchers was the PDP-10 with 4 MB of RAM. It could take up to 100 minutes to decode 30 seconds of speech. Practical products included: 1984 – the Apricot Portable was released with up to 4096 words support, of which only 64 could be held in RAM at a time. 1987 – a recognizer from Kurzweil Applied Intelligence 1990 – Dragon Dictate, a consumer product released in 1990. AT&T deployed the Voice Recognition Call Processing service in 1992 to route telephone calls without a human operator. The technology was developed by Lawrence Rabiner and others at Bell Labs. By the early 1990s, the vocabulary of the typical commercial speech recognition system had exceeded the average human vocabulary. Reddy's former student, Xuedong Huang, developed the Sphinx-II system at CMU. Sphinx-II was the first to do speaker-independent, large vocabulary, continuous speech recognition, and it won DARPA's 1992 evaluation. Handling continuous speech with a large vocabulary was a major milestone. Huang later founded the speech recognition group at Microsoft in 1993. Reddy's student Kai-Fu Lee joined Apple, where, in 1992, he helped develop the Casper speech interface prototype. Lernout & Hauspie, a Belgium-based speech recognition company, acquired other companies, including Kurzweil Applied Intelligence in 1997 and Dragon Systems in 2000. L&H was used in Windows XP. L&H was an industry leader until an accounting scandal destroyed it in 2001. L&H speech technology was bought by ScanSoft, which became Nuance in 2005. Apple licensed Nuance software for its digital assistant Siri. ==== 2000s ==== In the 2000s, DARPA sponsored two speech recognition programs: Effective Affordable Reusable Speech-to-Text (EARS) in 2002, followed by Global Autonomous Language Exploitation (GALE) in 2005. Four teams participated in EARS: IBM; a team led by BBN with LIMSI and the University of Pittsburgh; Cambridge University; and a team composed of ICSI, SRI, and the University of Washington. EARS funded the collection of the Switchboard telephone speech corpus, which contained 260 hours of recorded conversations from over 500 speakers. The GALE program focused on Arabic and Mandarin broadcast news. Google's first effort at speech recognition came in 2007 after recruiting Nuance researchers. Its first product, GOOG-411, was a telephone-based directory service. Since at least 2006, the U.S. National Security Agency has employed keyword spotting, allowing analysts to index large volumes of recorded conversations and identify speech containing "interesting" keywords. Other government research programs focused on intelligence applications, such as DARPA's EARS program and IARPA's Babel program. In the early 2000s, speech recognition was dominated by hidden Markov models combined with feed-forward artificial neural networks (ANN). Later, speech recognition was taken over by long short-term memory (LSTM), a recurrent neural network (RNN) published by Sepp Hochreiter & Jürgen Schmidhuber in 1997. LSTM RNNs avoid the vanishing gradient problem and can learn "Very Deep Learning" tasks that require memories of events that happened thousands of discrete time steps earlier, which is important for speech. Around 2007, LSTMs trained with Connectionist Temporal Classification (CTC) began to outperform. In 2015, Google reported a 49 percent error‑rate reduction in its speech recognition via CTC‑trained LSTM. Transformers, a type of neural network based solely on attention, were adopted in computer vision and language modelling, and then to speech recognition. Deep feed-forward (non-recurrent) networks for acoustic modelling were introduced in 2009 by Geoffrey Hinton and his students at the University of Toronto, and by Li Deng and colleagues at Microsoft Research. In contrast to the prioer incremental improvements, deep learning decreased error rates by 30%. Both shallow and deep forms (e.g., recurrent nets) of ANNs had been explored since the 1980s. Howev
Line detection
In image processing, line detection is an algorithm that takes a collection of n edge points and finds all the lines on which these edge points lie. The most popular line detectors are the Hough transform and convolution-based techniques. == Hough transform == The Hough transform can be used to detect lines and the output is a parametric description of the lines in an image, for example ρ = r cos(θ) + c sin(θ). If there is a line in a row and column based image space, it can be defined ρ, the distance from the origin to the line along a perpendicular to the line, and θ, the angle of the perpendicular projection from the origin to the line measured in degrees clockwise from the positive row axis. Therefore, a line in the image corresponds to a point in the Hough space. The Hough space for lines has therefore these two dimensions θ and ρ, and a line is represented by a single point corresponding to a unique set of these parameters. The Hough transform can then be implemented by choosing a set of values of ρ and θ to use. For each pixel (r, c) in the image, compute r cos(θ) + c sin(θ) for each values of θ, and place the result in the appropriate position in the (ρ, θ) array. At the end, the values of (ρ, θ) with the highest values in the array will correspond to strongest lines in the image == Convolution-based technique == In a convolution-based technique, the line detector operator consists of a convolution masks tuned to detect the presence of lines of a particular width n and a θ orientation. Here are the four convolution masks to detect horizontal, vertical, oblique (+45 degrees), and oblique (−45 degrees) lines in an image. a) Horizontal mask(R1) (b) Vertical (R3) (C) Oblique (+45 degrees)(R2) (d) Oblique (−45 degrees)(R4) In practice, masks are run over the image and the responses are combined given by the following equation: R(x, y) = max(|R1 (x, y)|, |R2 (x, y)|, |R3 (x, y)|, |R4 (x, y)|) If R(x, y) > T, then discontinuity As can be seen below, if mask is overlay on the image (horizontal line), multiply the coincident values, and sum all these results, the output will be the (convolved image). For example, (−1)(0)+(−1)(0)+(−1)(0) + (2)(1) +(2)(1)+(2)(1) + (−1)(0)+(−1)(0)+(−1)(0) = 6 pixels on the second row, second column in the (convolved image) starting from the upper left corner of the horizontal lines. page 82 == Example == These masks above are tuned for light lines against a dark background, and would give a big negative response to dark lines against a light background. == Code example == The code was used to detect only the vertical lines in an image using Matlab and the result is below. The original image is the one on the top and the result is below it. As can be seen on the picture on the right, only the vertical lines were detected
Shape analysis (digital geometry)
This article describes shape analysis to analyze and process geometric shapes. == Description == Shape analysis is the (mostly) automatic analysis of geometric shapes, for example using a computer to detect similarly shaped objects in a database or parts that fit together. For a computer to automatically analyze and process geometric shapes, the objects have to be represented in a digital form. Most commonly a boundary representation is used to describe the object with its boundary (usually the outer shell, see also 3D model). However, other volume based representations (e.g. constructive solid geometry) or point based representations (point clouds) can be used to represent shape. Once the objects are given, either by modeling (computer-aided design), by scanning (3D scanner) or by extracting shape from 2D or 3D images, they have to be simplified before a comparison can be achieved. The simplified representation is often called a shape descriptor (or fingerprint, signature). These simplified representations try to carry most of the important information, while being easier to handle, to store and to compare than the shapes directly. A complete shape descriptor is a representation that can be used to completely reconstruct the original object (for example the medial axis transform). == Application fields == Shape analysis is used in many application fields: archeology for example, to find similar objects or missing parts architecture for example, to identify objects that spatially fit into a specific space medical imaging to understand shape changes related to illness or aid surgical planning virtual environments or on the 3D model market to identify objects for copyright purposes security applications such as face recognition entertainment industry (movies, games) to construct and process geometric models or animations computer-aided design and computer-aided manufacturing to process and to compare designs of mechanical parts or design objects. == Shape descriptors == Shape descriptors can be classified by their invariance with respect to the transformations allowed in the associated shape definition. Many descriptors are invariant with respect to congruency, meaning that congruent shapes (shapes that could be translated, rotated and mirrored) will have the same descriptor (for example moment or spherical harmonic based descriptors or Procrustes analysis operating on point clouds). Another class of shape descriptors (called intrinsic shape descriptors) is invariant with respect to isometry. These descriptors do not change with different isometric embeddings of the shape. Their advantage is that they can be applied nicely to deformable objects (e.g. a person in different body postures) as these deformations do not involve much stretching but are in fact near-isometric. Such descriptors are commonly based on geodesic distances measures along the surface of an object or on other isometry invariant characteristics such as the Laplace–Beltrami spectrum (see also spectral shape analysis). There are other shape descriptors, such as graph-based descriptors like the medial axis or the Reeb graph that capture geometric and/or topological information and simplify the shape representation but can not be as easily compared as descriptors that represent shape as a vector of numbers. From this discussion it becomes clear, that different shape descriptors target different aspects of shape and can be used for a specific application. Therefore, depending on the application, it is necessary to analyze how well a descriptor captures the features of interest.
G'MIC
G'MIC (GREYC's Magic for Image Computing) is a free and open-source framework for image processing. It defines a script language that allows the creation of complex macros. Originally usable only through a command line interface, it is currently mostly popular as a GIMP plugin, and is also included in Krita. G'MIC is dual-licensed under CECILL-2.1 or CECILL-C. == Features == G'MIC's graphical interface is notable for its noise removal filters, which came from an earlier project called GREYCstoration by the same authors. G'MIC offers many built-in commands for image processing, including basic mathematical manipulations, look up tables, and filtering operations. More complex macros and pipelines built out of those commands are defined in its library files. == Interpreters == === Command line === G'MIC is primarily a script language callable from a shell. For example, to display an image: This command displays the image contained in the file image.jpg and allows zooming in to examine values. Several filters can be applied in succession. For example, to crop and resize an image: === Graphical interface === G'MIC comes with a Qt-based graphical interface, which may be integrated as a Gimp or Krita plugin. It contains several hundred filters written in the G'MIC language, dynamically updated through an internet feed. The interface provides a preview and setting sliders for each filter. G'MIC is one of the most popular Gimp plugins. === G'MIC Online === Most of the filters available for the graphical interface are also available online. === ZArt === ZArt is a graphical interface for real-time manipulation of webcam images. === libgmic === Libgmic is a C++ library that can be linked to third-party applications. It sees integration in Flowblade and Veejay.
Non-separable wavelet
Non-separable wavelets are multi-dimensional wavelets that are not directly implemented as tensor products of wavelets on some lower-dimensional space. They have been studied since 1992. They offer a few important advantages. Notably, using non-separable filters leads to more parameters in design, and consequently better filters. The main difference, when compared to the one-dimensional wavelets, is that multi-dimensional sampling requires the use of lattices (e.g., the quincunx lattice). The wavelet filters themselves can be separable or non-separable regardless of the sampling lattice. Thus, in some cases, the non-separable wavelets can be implemented in a separable fashion. Unlike separable wavelet, the non-separable wavelets are capable of detecting structures that are not only horizontal, vertical or diagonal (show less anisotropy). == Examples == Red-black wavelets Contourlets Shearlets Directionlets Steerable pyramids Non-separable schemes for tensor-product wavelets